Highlights of prescribing information coadministration of. When using an intravenous infusion pump, administer integrilin undiluted directly from the 100ml vial. Dexamethasone sodium phosphate injection can be given directly from the vial, or it can be added to sodium chloride injection or dextrose injection and administered by intravenous drip. Some health conditions may make you more susceptible to the sideeffects of the drug. Insert the needle of the syringe into a 20 cm pe10 tube. Asnc imaging guidelines asnc imaging guidelines for. Dobutamine dobutamine hydrochloride dose, indications. Each 20ml contains dobutamine hydrochloride equivalent to 250mg dobutamine each 1ml contains dobutamine hydrochloride equivalent to 12. This products label may have been revised after this insert was used in production.
Most clinical experience with dobutamine is shortterm, up to several hours in duration. Levophed norepinephrine this product information is intended only for residents of the united states. Each 100 ml contains dobutamine hydrochloride equivalent to 100 mg, 200 mg, or 400 mg of dobutamine. A healthcare provider will give you this injection. Cytarabine injection, an antineoplastic, is a sterile solution of cytarabine for intravenous and subcutaneous use which contains no preservative and is available in 20 mgml mg50 ml pharmacy bulk package.
The flexible containers provide two readytouse dilutions of milrinone in volumes of 100 ml and 200 ml of 5% dextrose injection. Fill a 1 ml syringe 29gx12 with dobutamine working solution. Side effects and frequent adverse reactions include chest pain, headache, fever, shortness of breath, increased blood pressure. Urinary output can increase, however, secondary to increased. Asnc imaging guidelines asnc imaging guidelines for spect nuclear cardiology procedures. Vfend is an azole antifungal indicated for the treatment of adults and pediatric patients 2 years of age and older with. Dobutamine hydrochloride in 5% dextrose injection is a sterile, nonpyrogenic solution of dobutamine hydrochloride, usp and dextrose, usp in water for injection, usp. The practitioner should be familiar with the package insert for each medication. Dailymed dobutamine hydrochloride in dextrose dobutamine. Dobutamine has minimal effect on pulmonary vascular resistance. Store diluted product in accordance with package insert instructions. Brevibloc injection is indicated for the rapid control of ventricular rate in patients with atrial fibrillation or atrial flutter in perioperative, postoperative, or other emergent circumstances where short term control of ventricular rate with a shortacting agent is desirable.
Dobutamine side effects, dosage, interactions drugs everyday health search. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Lidocaine hydrochloride injection, usp, 2% for infiltration. Insert a plastic intravenous catheter through a suitable bore needle well advanced centrally into the vein and securely fixed with adhesive tape, avoiding, if possible, a catheter tiein technique as this promotes stasis. Protamine sulfate injection, usp is a sterile, isotonic solution of protamine sulfate. Levophed norepinephrine bitartrate injection, usp rx. Dobutamine hydrochloride is chemically designated as 423phydroxyphenyl1methylpropylaminoethylpyrocatechol hydrochloride. Dobutamine stimulates heart muscle and improves blood flow by helping the heart pump better. Highlights of prescribing information these highlights do not include all the information needed to use humulinnsafely and effectively. Dobutamine hydrochloride in 5% dextrose injection contains sodium bisulfite, a sulfite that may cause allergictype reactions, including anaphylactic symptoms and life threatening or less severe asthmatic episodes, in certain susceptible people. Mar 27, 2019 dobutamine hydrochloride in 5% dextrose injection is indicated when parenteral therapy is necessary for inotropic support in the shortterm treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures. Where multiple infusions are required, it may be acceptable to administer dobutamine with other inotropes, via a threeway tap.
Adenoscan should be used with caution in patients with obstructive lung disease not associated with bronchoconstriction e. Nov 01, 2019 dobutamine injection, usp is a clear, practically colorless, sterile, nonpyrogenic solution of dobutamine hydrochloride for intravenous use only. A calibrated electronic infusion device is recommended for controlling the rate of. Bystolic may be used alone or in combination with other antihypertensive agents see drug interactions 7. Imaging guidelines for nuclear cardiology procedures. Primacor milrinone lactate injection 200 mcgml in 5% dextrose injection description primacor, brand of milrinone lactate injection, is a member of a class of bipyridine inotropicvasodilator agents with phosphodiesterase inhibitor activity, distinct from digitalis glycosides or catecholamines. Dosages greater than 200 mcg per kg per minute provide little. Dobutamine in 5% dextrose injection, usp is administered intravenously through a suitable intravenous catheter or needle. Additionally, difficulty in restarting and maintaining the heartbeat has been reported with. Feb 10, 20 dilute dobutamine stock solution in sterile 0. Esophageal candidiasis serious fungal infections caused by scedosporium apiospermum and fusarium species including fusarium solani, in patients intolerant of, or refractory. Dobutamine must always be administered via a dedicated lumen, and never piggybacked with other drugs or fluids.
Highlights of prescribing information hypotension, throat. What dobutamine concentrate looks like and contents of pack dobutamine concentrate is a clear, colourless or almost colourless sterile concentrate for solution for infusion. Protamine sulfate is intended for injection without further dilution. Dobutamine in 5% dextrose injection, usp flexible plastic. However, since cmv usually causes latent infections and since foscarnet, like. Administer integrilinby volume according to patient weightsee table1. Cardiac stress test induced by dobutamine and monitored by.
Unlike dopamine, dobutamine does not affect dopaminergic receptors, nor does it cause release of norepinephrine from sympathetic nerve endings. Dobutamine is a directacting inotropic agent whose primary activity results from stimulation of the. Dobutamine infusions must be administered by syringe pump or infusion pump. The effective maintenance dose for continuous and stepwise dosing is 50 to 200 mcg per kg per minute, although doses as low as 25 mcg per kg per minute have been adequate. Preparations of angiomax containing particulate matter should not be used. Dec 31, 2019 protamine sulfate injection should be given by very slow intravenous injection over a 10minute period in doses not to exceed 50 mg see warnings. Package insert protamine sulfate injection, usppiengv1. Highlights of prescribing information sinoatrial sa.
However, such patients may be subject to protracted severe hypotension. The package insert states that there is no proven successful management of extravasation after it occurs, although sympathetic block and heparinization are commonly employed during acute management. It does not cause the release of endogenous norepinephrine, as does dopamine. Read all of this leaflet carefully before you start using this medicine. The clinical formulation is supplied in a sterile form for intravenous use only. In the us, dobutamine dobutamine systemic is a member of the following drug classes. Dobutamine hydrochloride in 5% dextrose injection is a sterile, nonpyrogenic solution.
Dailymed protamine sulfate protamine sulfate injection. A list of us medications equivalent to dobutamine is available on the drugs. Invasive aspergillosis candidemia in nonneutropenics and other deep tissue candida infections. For further product information and current package insert, please visit. If you use other drugs or over the counter products at the same time, the effects of dobutamine fresenius injection may change. Sulfuric acid andor dibasic sodium phosphate heptahydrate may have been added for ph adjustment. Dobutamine injection usp page 4 of caution should also be used in patients taking concomitantly other sympathomimetic amines. Humulinn isophane insulinhumansuspension, for subcutaneous use initial u. Dobutamine may be associated with sinus tachycardia or premature ventricular contractions pvcs due to its stimulatory effect on cardiac conduction.
Dobutamine was compatible at concentrations up to 4 mgml but incompatible at a concentration of 12. Center the spike within the circle on the stopper top. Dobutamine is indicated when parenteral therapy is necessary for inotropic support in the shortterm treatment of adults with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures. Adenosine induces direct coronary arteriolar vasodilation through speci. Medication dosing identified in this realworld evaluation was compared to recommendations in the package insert. Nov 09, 2018 dobutamine is injected into a vein through a catheter.
Dobutamine hydrochloride is chemically designated as 423phydroxyphenyl1 methylpropylaminoethylpyrocatechol hydrochloride. Insert piercing pin of administration set into port with a twisting motion until the set is. Indications for brevibloc esmolol hcl injection supraventricular tachycardia. Dobutamine is prescribed to assist with cardiac output in a person with a failing heart due to heart disease or cardiac surgery. Dexamethasone sodium phosphate injection, 10 mgml for intravenous and intramuscular injection only. You will receive this medicine in a hospital or clinic setting to quickly treat any. Dobutamine is a medicine available in a number of countries worldwide. Dobutamine injection is a prescription drug in the drug class of catecholamines. Dobutamine in dextrose fda prescribing information, side. Highlights of prescribing information sinoatrial sa and. It takes spikes, syringes, and pumps to make an intravenous iv solution. Each ml contains milrinone lactate equivalent to 200 mcg milrinone.
Pretreatment of dogs with reserpine or desmethyl imipramine does not alter the actions of dobutamine. Dobutamine hydrochloride is a directacting inotropic agent whose primary activity results from stimulation of the betareceptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. Dobutamine in 5% dextrose injection, usp flexible plastic container rx only description dobutamine in 5% dextrose injection, usp is a sterile, nonpyrogenic, prediluted solution of dobutamine hydrochloride and dextrose in water for injection. The patient should also be monitored for discontinuation symptoms of the antidepressant see package insert of the specified agents for a description of the associated discontinuation symptoms.
In the limited number of patients who were studied for 24, 48, and 72 hours, a persistent increase. The indication for treatment of acyclovir resistant hsv infections in immunocompromised patients with hiv infections is based primarily on the results of one open label comparative study. In animal studies, dobutamine produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoprenaline. The prospectively defined primary efficacy end point was the rate of vtvf episodes per hour. Dobutamine may precipitate or exacerbate ventricular ectopic activity. Each vial of digifab, which will bind approximately 0. Full prescribing information 1 indications and usage lexiscan regadenoson injection is a pharmacologic stress agent indicated for radionuclide myocardial perfusion imaging mpi in patients unable to undergo adequate exercise stress. Dobutamine side effects, dosage, interactions drugs. Levophed norepinephrine bitartrate dose, indications. For the purposes of this policy, an accredited rn is. A realworld, multicenter assessment of drugs requiring. This may increase your risk for sideeffects or cause your drug not to work properly.
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